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WinNonlin ® Version 5.2 WinNonlin copyright ©1998-2007 Pharsight Corporation. All rights reserved. This software and documentation are owned by Pharsight Corporation, and may be used only as authorized in the license agreement controlling such use. No part of the software nor the accompanying documentation may be reproduced, transmitted, or translated, in any form or by any means, electronic, mechanical, manual, optical, or otherwise, except as expressly provided by the license agreement or with the prior written permission of Pharsight Corporation. This product may contain the following software that is provided to Pharsight Corporation under license: Actuate Formula One® copyright 1993-03 Actuate, Inc. All rights reserved. SentinelLM 6.0 copyright 1998 Rainbow Technologies, Inc. All rights reserved. Microsoft® XML Parser version 3.0 copyright 1998- 2000 Microsoft Corporation. All rights reserved. IMSL® copyright 1993 Visual Numerics, Inc. All rights reserved. Information in the documentation is subject to change without notice and does not represent a commitment on the part of Pharsight Corporation. The documentation contains information proprietary to Pharsight Corporation and is for use by Pharsight Corporation customers only. Use of the information contained in the documentation for any purpose other than that for which it is intended is not authorized. NEITHER PHARSIGHT CORPORATION NOR ANY OF THE CONTRIBUTORS TO THIS DOCUMENT MAKES ANY REPRESENTATION OR WAR- RANTY, NOR SHALL ANY WARRANTY BE IMPLIED, AS TO THE COMPLETENESS, ACCURACY, OR USEFULNESS OF THE INFORMATION CONTAINED IN THIS DOCUMENT, NOR DO THEY ASSUME ANY RESPONSIBILITY FOR LIABILITY OR DAMAGE OF ANY KIND WHICH MAY RESULT FROM THE USE OF SUCH INFORMATION. Destination Control Statement All technical data contained in the software and documentation are subject to the export control laws of the United States of America. Disclosure to nationals of other countries may violate such laws. It is the reader's responsibility to determine the applicable regulations and to comply with them. United States Government Rights The software and documentation constitute “commercial computer software” and “commercial computer software documentation” as such terms are used in 48 CFR 12.212 (Sept. 1995). United States Government end users acquire the software under the following terms: (i) for acquisition by or on behalf of civilian agencies, consistent with the policy set forth in 48 CFR 12.212 (Sept. 1995); or (ii) for acquisition by or on behalf of units of the Department of Defense, consistent with the policies set forth in 48 CFR 227.7202-1 (June 1995) and 227.7202-3 (June 1995). The manufacturer is Pharsight Corporation, 321 E. Evelyn Ave., 3rd Floor, Mountain View, CA 94041. Trademarks PK Automation Application, PKS, Pharsight Knowledgebase Server and Trial Simulator are trademarks of Pharsight Corporation. Pharsight, WinNonlin, IVIVC Toolkit for WinNonlin, WinNonMix, Drug Model Explorer and DMX are registered trademarks of Pharsight Corporation. SAS and all other SAS Institute Inc. product or service names are registered trademarks or trademarks of SAS Institute Inc. in the USA and other countries. SigmaPlot is a registered trademark of Systat Software, Inc. S-PLUS is a registered trademark of Insightful Corporation. NONMEM is a registered trademark of The Regents of the University of California. Actuate is a trademark and Formula One is a registered trademark of Actuate Corporation. SentinelLM is a trademark of Rainbow Technologies, Inc. Microsoft, the Internet Explorer logo, MS-DOS, the Office logo, PowerPoint, Visual C++, Visual Studio, Windows, the Windows logo, Windows NT, the Windows Start logo and XL design (the Microsoft Excel logo) are registered trademarks of Microsoft Corporation. Pentium and Pentium III are trademarks or registered trademarks of Intel Corporation. Adobe, Acrobat, Acrobat Reader and the Adobe PDF logo are registered trademarks of Adobe Systems Incorporated. IMSL is a registered trademark of Visual Numerics, Inc. Compaq Visual Fortran is trademark of Compaq Computer Corporation. All other brand or product names mentioned in this documentation are trademarks or registered trademarks of their respective companies or organizations. Pharsight Corporation 321 E. Evelyn Ave., 3rd Floor, Mountain View, California 94041 Voice +1-650-314-3800 • Fax +1-650-314-3810 http://www.pharsight.com • support@pharsight.com

Contents Chapter 1 Installation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 System requirements. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 WinNonlin Professional . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 WinNonlin Enterprise. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Installing WinNonlin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Pharsight common files . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Temporary files directory. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Installing WinNonlin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Additional requirements for installation on Citrix . . . . . . . . . . . . . . . . . 10 Chapter 2 Licensing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11 The license key code and product tracking ID . . . . . . . . . . . . . . . . . . . . . . . 11 Existing license key codes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Installing a node license key code. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Installing a floating license key code . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Renewing a floating license key code. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Installing an IVIVC License . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 License Keycode and Tracking ID . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Chapter 3 Testing the Installation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .19 File and window operations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Confirming license installation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Loading a file . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Creating a chart. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 Creating a table. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 iii

• Page 1: WinNonlin ® Getting Started Guide
• Page 5 and 6: Chapter 1 Installation System requi
• Page 7 and 8: Installation Installing WinNonlin 1
• Page 9 and 10: Installation Installing WinNonlin 1
• Page 11 and 12: Installation Installing WinNonlin 1
• Page 13 and 14: Installation Installing WinNonlin 1
• Page 15 and 16: Chapter 2 Licensing Installation an
• Page 17 and 18: Licensing Installing a node license
• Page 19 and 20: Licensing Installing a floating lic
• Page 21 and 22: Licensing Installing an IVIVC Licen
• Page 23 and 24: Chapter 3 Testing the Installation
• Page 25 and 26: Testing the Installation File and w
• Page 27 and 28: Testing the Installation File and w
• Page 29 and 30: Testing the Installation File and w
• Page 31 and 32: Testing the Installation File and w
• Page 33 and 34: Testing the Installation File and w
• Page 35 and 36: Testing the Installation Modeling 3
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• Page 41 and 42: Testing the Installation Modeling 3
• Page 43 and 44: Testing the Installation Modeling 3
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• Page 47 and 48: Testing the Installation Modeling 3
• Page 49 and 50: Testing the Installation Modeling 3
• Page 51 and 52: Testing the Installation Bioequival
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  Testing the Installation Bioequival

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  Testing the Installation Bioequival English grammar today murat kurt pdf viewer.

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  Index A Anti-virus software, 4 B Bi